Chloride-dependent enhancement by barbiturates of gamma-aminobutyric acid receptor binding
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منابع مشابه
Chloride-dependent enhancement by barbiturates of gamma-aminobutyric acid receptor binding.
Barbiturates enhance GABA receptor (sodium-independent) binding at 0°C to bovine brain membranes about 2-fold in chloride-containing buffer but not in chloride-free phosphate or Tris/ citrate buffer. This effect is observed in frozen and thawed, thoroughly washed membranes from various regions of bovine brain as well as washed membranes prepared from unfrozen rat cerebral cortex; it is destroye...
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The high-affinity of [3H]gamma-aminobutyric acid (GABA) to GABAA receptors and [3H]baclofen to GABAB receptors were studied in the cerebellum of pyridoxine-deficient rats and compared to pyridoxine-supplemented controls. There was a significant increase in the maximal binding (Bmax) of both GABAA and GABAB receptors with no significant difference in their binding affinities (Kd). The changes ob...
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Interaction of intoxicant-anesthetic drugs with the gamma-aminobutyric acid (GABA) receptor-chloride channel complex of mouse brain was studied using the binding of [35S]t-butylbicyclophosphorothionate (TBPS) to isolated membranes and the GABA-stimulated uptake of 36Cl- by membrane vesicles. Anesthetic drugs, including barbiturates, chloroform, diethylether and ethanol, inhibited the binding of...
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Lanthanum was previously reported to potentiate the GABA-induced chloride currents reversibly by acting at a distinct site on the GABAA receptor-channel complex (Ma and Narahashi, 1993). We now report that all other lanthanides tested enhanced the GABA responses with greater efficiencies and produced inward currents by themselves. The rank order of efficacies of lanthanides to potentiate the GA...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1982
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.02-12-01812.1982